【个人简介】

姓名：吕鹏

性别：男

出生日期：1983.12

职称：副研究员

E-mail：penglu@ujs.edu.cn

【学术简介】

学习经历：

2002-2006 年 江苏大学大学 生物技术

2006-2009 年 江苏大学 生物化学与分子生物学

2011-2014 年 江苏大学 食品营养与安全

工作经历：

2009-2010 年 中国科学院上海巴斯德研究所

2010-2011 年 北京西美杰科技有限公司

2014-至今 江苏大学生命科学研究院

【主讲课程】

本科生：抗体工程

研究生：生物仪器分析与实验技术，生命科学进展

【研究领域】

昆虫病毒与宿主相互作用机制；

基因工程抗体筛选及应用（单 B 抗体筛选平台，噬菌体抗体库平台，检测试剂，CAR-T）；

基于 CRISPR/Cas 系统的生物检测方法及产品开发。

【科研项目】

1. 镇江市重点研发计划（NY2023007），基于 CRISPR/Cas 生物传感技术的非

洲猪瘟快速检测研究，主持，在研

2. 江苏省重点研发计划（BE2017651），应用基因工程抗体的新型尿液检测雌酮

孕酮（荧光定量免疫层析法）POCT 产品的研发，主持，在研；

3. 国家自然基金青年基金（31602008），家蚕蛋白 MyosinII 在 BmNPV 诱导

宿主自噬以及病毒复制增殖中的作用机制研究，主持，在研；

4. 镇江市重点研发计划（SH2016013），应用于新型尿液检测雌酮孕酮产品的基

因工程抗体的筛选，主持，结题；

5. 江苏省自然基金青年基金（BK20150495），家蚕羧酸酯酶 Bmae45 及其抗

BmNPV 机制研究，主持，结题；

6. 中国博士后科学基金（2015M571701），家蚕自噬在杆状病毒 BmNPV 感染

增殖中的作用机制研究，主持，在研；

7. 横向课题（江苏美正生物），农残快速检测生物性原料筛选和制备，主持；

8. 横向课题（南京师范大学），FEN1 人源化抗体的筛选，主持；

9. 横向课题（上海触研生物），肺癌筛查检测产品研发，主持；

10. 横向课题（江苏维尔生物），生殖相关检测产品研发，主持；

11. 横向课题（上海瑞宙生物），猪相关疫苗研发，主持。 【主要论著】

2023 年

1. Songlin Qiu, Ye Pan, Zhigang Guo*, Peng Lü*, Genetic mechanism of

leukemia relapse following CD19 chimeric antigen receptor T-cell

therapy, Cancer Biotherapy and Radiopharmaceuticals, 2023. 2. RS Yuan, J Wei, R Geng, B Li, F Xiong, X Fang, P Lü#, K Wang#, Ultra-sensitive photoelectrochemical biosensor for determination of

Afreican swine fever virus based on surface plasmon resonance, Analytica

chimica acta, 2023. 2022 年

1. Funmilayo O. Fapohunda, Seng Qiao, Ye Pan, Huiying Wang, Yuan

Liu, Peng Lü*, CRISPR Cas system: a strategic approach in detection of

nucleic acids, Microbiological Research, 2022, In press. 2. R. Liu, SA Haruna, S Ali, J Xu, YL Zhang, P Lü, HH Li, QS Chen, A

sensitive and accurate fluorescent genosensor for Staphylococcus aureus

detection, Sensors and actuators B-Chemial,2022. 2021 年

1. Peng Lü, Songlin Qiu, Ye Pan, Shenyan Shi, Qian Yu, Feng Yu, Lianjun Miao, Huiying Wang, Keping Chen, Discovery of an

Heparin-binding epidermal growth factor domain antibody from a phage

library and analysis of its inhibitory effects in SKOV3 cells, Cancer

Biotherapy and Radiopharmaceuticals, 2021, online ahead of print. 2. Min Tang, Suqun He, Xun Gong, Peng Lü, Reha H Taha, Keping

Chen, High-Quality de novo chromosome-level genome assembly of a

single Bombyx mori with BmNPV resistance by a combination of PacBio

long-reading sequencing, Illumina Short-read sequencing, and Hi-C

sequencing, Frontiers in Genetics, 2021, 12. 3. Qian Yu, Pengfei Chang, Xiaoxuan Liu, Peng Lü, Qi Tang, Zhongjian

Guo, Jianming Qiu, Keping Chen, Qin Yao, Bombyx mori pupae

efficiently produce recombinant AAV2/HBoV1 vectors with a Bombyx

mori nuclear polyhedrosis virus expression system, Viruses, 2021, 13(4), 704. 4. Rui Liu, Suleiman A Haruna, Shujat Ali, Jing Xu, Yunlian Zhang, Peng

Lü, Huanhuan Li, Quansheng Chen, A sensitive and accurate fluorescent

genosensor for Staphylococcus aureus detection, Sensors and Actuators B:

Chemical, 131311. 5. Yuan Liu, Shu Liu, Chongxin Xu, Manman Lin, Yihang Li, Cheng

Shen, Ying Liang, Xing Sun, Donglan Wang, Peng Lü, Xianjin Liu, Epitopes prediction for microcystin-LR by molecular docking, Ecotoxicology and Environmental Safety, 2021, 227, 112925. 2020 年

1. Peng Lü*#, Songlin Qiu#, Ye Pan, Feng Yu, Keping Chen, Pre-clinical

CAR-T progress in digestive system cancers, Cancer Biotherapy and

Radiopharmaceuticals, 2020, 36(4), 307-315. 2. Zhichao Nie#, Peng Lü#, Min Tu, Zhanzhuang Zeng, Rusong Zhang, Yishuai Tu, Zhenni Liu, Yin Li, Hong Zhang*, a simple and rapid method

for fish sex identification based on recominase-aided amplification: an

example of Cynoglossus semilaevis, Scientific Reports, 2020, 11(1), 1-11. 3. Xue Han#, Peng Lv#, Luguang Wang, Fei Long, Xiaolin Ma, Chang

Liu, Yujie Feng, Mingfeng Yang and Xiang Xiao*, Impact of nano-TiO2

on horizontal transfer of resistance genes mediated by filamentous phage

transduction, Environmental Science Nano, 2020,4. 4. Feifei Zhu, Dong Li, Dandan Song, Shuhao Huo, Shangshang

Ma, Peng Lü, Xiaoyong Liu, Qin Yao, Keping Chen, Glycoproteome in

silkworm Bombyx mori and alteration by BmCPV infection, Journal of

Proteomics, 222, 103802.

2019 年

1. Peng Lü, Yaling He, Feng Lin, Ye Pan, Qian Yu, Zhongjian Guo, Chengjun Li, Huiying Wang, Qin Yao*, Yan Fu* and Keping Chen*, Rapid detection of Bombyx mori bidensovirus by loop-mediated

isothermal amplification based lateral flow dipstick assay for field

applications, Journal of Invertebrate Pathology, 2019, 163:75-81. 2. Rui Li, Pengfei Chang, Peng Lü, Zhaoyang Hu, Keping Chen Qin Yao, Qian Yu, Characterization of the RNA transcription profile of Bombyx

mori Bidensovirus, Viruses, 2019, 11(4), 325. 2018 年

1. Peng Lü, Ye Pan, Yanhua Yang, Feifei Zhu, Chengjun Li, Qin Yao and

Keping Chen*, Discovery of anti-viral molecules and their vital functions

in Bombyx mori, Journal of Invertebrate Pathology, 2018, 154: 12-18. 2014-2017 年

1. Peng Lü, Yali Xing, Zhaoyang Hu, Yanhua Yang, Ye Pan, Kangmin

Chen, Feifei Zhu, Yajing Zhou, Keping Chen and Qin Yao*, A

characterization of structural proteins expressed by Bombyx mori

bidensovirus, Journal of Invertebrate Pathology, 2017, 144: 18-23。

2. Ye Pan, Peng Lü, Qinyun Wang, Feifei Zhu, Chengjun Li, Yuanqing

He and Keping Chen*, Comparative transcriptomic analysis of Bombyx

mori fat body tissue following dietary restriction, Archives of Insect

Biochemistry and Physiology, 2017, 95(1): e21388. 3. Zhichao Nie, Peng Lü*, Qiang Wang, Xu Meng, Shuang Lu, Xin Dong

and Keping Chen*, Reference gene selection for quantitative real-time

polymerase chain reaction analysis in Bombyx mori

nucleopolyhedrovirs-infected silkworms, Invertebrate Survival Journal, 2017, 14: 94-102. 4. Xin Dong, Peng Lü, Wu Cao, Chi Zhang, Feifei Zhu, Xu Meng, Zhichao Nie, Shuang Lu and Keping Chen*, Study of the toxicity of

Bacillus cereus on silkworm (Bombyx mori) and the relevant proteome, Invertebrate Survival Journal, 2017, 14: 129-139

5. Caixia Lian, Lingling Ruan, Dongsheng Shang, Yanfang Wu, Yongjin

Lu, Peng Lü, Yuhua Yang, Yajun Wei, Xiaojing Dong, Dewan Ren, Keping Chen, Hanqing Liu and Zhigang Tu*, Heparin-binding epidermal

growth factor-like growth factor as potent target for breast cancer therapy,

Cancer Biotherapy & Radiopharmaceuticals, 2016, 31(3): 85-90. 6. Zhicai Zhang*, Lili Xia, Feng Wang, Peng Lv, Maxiaoqi Zhu, Jinhua

Li and Keping Chen, Lignin degradation in corn stalk by combined

method of H2O2 hydrolysis and Aspergillus oryzae CGMCC5992

liguid-state fermentation, Biotechnology for Biofuels, 2015, 8(1): online. 7. Xiaoli Pan, Peng Lü, Miaomiao Zhang, Zhaoyang Hu, Guohui Li, Shangshang Ma, Fan Feng, Keping Chen, Qin Yao*, Expression Analysis

of Bombyx mori Bidensovirus Structural Proteins and Assembly of

Virus-like Particles in Insect Cells, Current Microbiology, 2014, 69(4):

567-573

2013 年

1. Peng Lü, Hengchuan Xia, Lu Gao, Ye Pan, Yong Wang, Xin Cheng, Honggang Lü, Feng Lin, Liang Chen, Qin Yao, Xiaoyong Liu, Qi Tang, Keping Chen*, V-ATPase Is Involved in Silkworm Defense Response

against Bombyx mori Nucleopolyhedroviurs, PLoS One, 2013, 8(6):

e64962. 2013 年以前

1. Peng Lü, Keping Chen*, Qin Yao, Lu Gao, Ye Pan, Yuanqing He, Guoping Huang, Lin Wang, Expression and Localization of Bombyx mori

V-ATPase 16 kDa Subunit c, Zeitschrift für Naturforschung C, 2010, 65(1-2): 119-126. 2. Ye Pan, Peng Lü, Yong Wang, Lijing Yin, Hexiang Ma, Guohong Ma, Keping Chen, Yuanqing He*, In silico identification of novel

chitinase-like proteins in the silkworm, Bombyx mori, genome, Journal of

Insect Science, 2012, 12. 【科研成果、教学成果及奖励】

1. 2016 年江苏省科技进步三等奖（4/7）

2. 2022 年“互联网+”江苏省产业赛道二等奖

【授权专利】

7 项，转化 3 项

【以上资料更新日期】

2024.3.29